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  Much of the work we do in HIV prevention is aimed at trying to stop people from engaging in behaviours that could expose them to HIV and potentially lead to infection. But what happens if someone thinks they may have already been exposed to HIV? Is there a way we can stop them from getting infected? Post-exposure prophylaxis, or PEP, could be an option.h

What is post-exposure prophylaxis(PEP)?

With PEP, an HIV-negative person who may have been exposed to HIV takes anti-HIV drugs prescribed by a doctor to prevent infection. These are the same drugs that people living with HIV take. PEP involves taking two or three of these drugs for a period of one month. To effectively reduce a person’s risk of becoming HIV-positive, PEP must be taken within 72 hours of possible exposure to HIV but ideally as early as possible.  In the world of PEP, exposure to HIV is often divided into two categories: occupational exposure and non-occupational exposure. “Occupational” exposure refers to exposure to HIV at work, in a healthcare setting. For example, a healthcare provider could be exposed to HIV through a needlestick injury at work. “Non-occupational” exposure refers to exposure to HIV through sex or drug use, for example, when a person shares a needle or has sex without a condom.

What is the rationale for PEP?

In the first one to three days following exposure to HIV, there is a ‘window of opportunity’ when taking PEP might prevent an HIV infection from occurring.1 During this ‘window of opportunity,’ the virus is busy infecting cells at the site of exposure (such as in the anus, penis or vagina). Once the virus is inside a cell, it starts replicating to produce more HIV (also known as virions). After a few days, these new HIV virions start to spread throughout the body; once this happens, infection is permanent. The theory is that if PEP is given to a person early enough, it can stop the virus from replicating at the initial site of exposure, preventing virions from spreading throughout the body – stopping the infection from becoming permanent. The cells that initially became infected would eventually die out and the virus would not be able to replicate.  

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